2018-05-29
The MORC1 gene has been suggested as a link between early life stress and major depression in humans as well as in animal models. Here, researchers from the Biopsychology department and the division of Experimental and Molecular Psychiatry investigated DNA methylation in the MORC1 promoter region in healthy human adults. In a non-clinical population, DNA methylation in the MORC1 promoter region was significantly correlated with the Beck Depression Inventory score. In contrast, DNA methylation was negatively associated with birth complications, an indicator of early life stress. These findings further confirm that MORC1 is a stress-sensitive gene and a possible biomarker for depression.
The MORC1 gene has been suggested as a link between early life stress and major depression in humans as well as in animal models. Here, researchers from the Biopsychology department and the division of Experimental and Molecular Psychiatry investigated DNA methylation in the MORC1 promoter region in healthy human adults. In a non-clinical population, DNA methylation in the MORC1 promoter region was significantly correlated with the Beck Depression Inventory score. In contrast, DNA methylation was negatively associated with birth complications, an indicator of early life stress. These findings further confirm that MORC1 is a stress-sensitive gene and a possible biomarker for depression.
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Last update: Sep 22, 2023
