Handedness is thought to originate in the brain, but identifying its structural correlates in the cortex has yielded surprisingly incoherent results. One idea proclaimed by several authors is that structural grey matter asymmetries might underlie handedness.
In the present study, a team from the Biopsychology lab investigated this idea using a new voxel-based morphometry toolbox. While there were several significant left-right asymmetries in the overall sample, no difference between left- and right-handers reached significance after correction for multiple comparisons. These findings indicate that the structural brain correlates of handedness are unlikely to be rooted in macroscopic grey matter area differences that can be assessed with VBM. Future studies should focus on other potential structural correlates of handedness, e.g. structural white matter asymmetries.

Ocklenburg, S., Friedrich, P., Güntürkün, O., Genc, E., Voxel-wise grey matter asymmetry analysis in left- and right-handers, Neuroscience Letters, 2016, 633: 210-214.